Women unable to sleep due to hot flashes

What to eat to get to sleep and stay asleep

Struggling to sleep? Cant get to sleep and when you do you wake up well before your alarm? Consequently you are feeling sleepy during the work day?

Why sleep is disturbed

Unfortunately, sleep disturbances are a core symptom of menopause (1-3). Insomnia increases around the time of menopause onset and is the most observed sleep disorder associated with menopause (4).

One of the reasons why sleep is affected by menopause is that menopause alters our bodies circadian rhythm with is the fluctuations in physiological processes and hormones across the day (24 hour period) including effects on sleep (5,6) Sleep is furthered impacted by the fact that aging in itself causes changes in the timing of sleep (5) with older adults preferring an earlier bedtime and wake time and they are more sensitive to the mismatch between desire for an actual sleep (7) impairing sleep duration and quality.

Nutrition

Nutrition Intervention

Isoflavones

A systematic review of nutritional interventions (8) showed both isoflavones and black cohosh have beneficial effects on sleep in menopausal women. Although exact mechanisms by which these nutrients might impact sleep is unknown. Isoflavone based foods such as soy are phytoestrogens and bind to estrogen receptors which could attenuate the effects of decreasing estrogen on sleep (9). Research investigating isoflavones or isoflavones in combination with other compounds have shown positive effects on subjective sleep (19). However, it should be noted that not all studies were positive, including 1 study that did not observe an effect upon sleepiness (19).The dosage may influence the degree of the therapeutic effect, as 1 study has found that a higher dose (25 mg daily) was more effective than a lower dose (12.5 mg) in the treatment of self-reported insomnia symptoms (20). A further, 3 studies indicated that soy or soybean could be beneficial in terms of subjective sleep. The benefits of soy products is likely due to their high isoflavone content. See isoflavone resource for more details on isoflavones.

Black cohosh

Black cohosh

Black Cohosh could affect neurotransmitters that modulate sleep/wake cycles. These neurotransmitters include serotonin (5-HT) and - γ-Aminobutyric acid (GABA) (10). The reseach has shown  black cohosh could improve subjective sleep problems (assessed on the basis of a menopausal symptom assessment) (24), and objective sleep, in terms of markers of nocturnal wake duration and objective sleep quality, relative to placebo, at six months follow-up (25).

Alcohol

Alcohol

Other factors that could help with sleep. Limit the total amount of alcohol and avoid it close to bed. Sleep after drinking alcohol is of poor quality. Objective measures of sleep show that alcohol consumption  suppresses REM sleep early in the night, but later it increases wakefulness (!2). Although some people belive alcohol improves their sleep possibly because they feel like they fall asleep quicker but the belief of improved sleep is a misconception (12).

Caffeine

Caffeine

Switch to decaffeinated drinks from noon, caffeine is a stimulant and known to decrease sleep duration and sleep latency (17). This doesn’t just refer to coffee but also fizzy drinks, energy drinks, tea and even chocolate contains caffeine. In fact try switching to a chamile tea. This is because chamomile preparations such as tea have traditionally been used to treat insomnia and to induce sedation (calming effects). Chamomile is widely regarded as a mild tranquillizer and sleep-inducer (18).

Other compounds

Other compounds

Many other compounds have been studied but the research is limited to only a single study. These compounds include pomegranate seed oil (26),pollen extracts (27),organic Maca (28),jujube seed capsule (29), and salvia extract (30),appear to benefit subjective sleep.

Meal timing

Meal timing

Meal timing in relation to bed time can impact sleep quality, don’t eat too close to bed. Plasma tryptophan levels peak 3–4 h after a meal (13,14). A crossover study found that having a meal 4 h before bedtime resulted in shorter sleep latency (the time from lights out to the first stage of sleep) than having a meal 1 h before bedtime (15). This study indicated that the time from dinner to bedtime affected sleep indices. A recent observational study showed that eating or drinking close to bedtime was associated with increased risks of reduced sleep duration, assessed based on a 24 h activity report (16). 

Personalise your approach

Get your food and symptoms diary

Finally, keep a food and symptoms journal to see if any particular foods or drinks really effect sleep.  Download the Fred Nutrition food and symptoms journal

Disclaimer

This information is for educational purposes only. You should contact your healthcare professional before you make any dietary changes or use any supplements. Supplements may also be contaminated and care should be taken when using them.

References

1.     NIH State-of-the-Science Conference Statement on management of menopause- related symptoms. NIH Consens State Sci Statements. 2005;22:1–38.

2.     Lee J, Han Y, Cho HH, et al. Sleep disorders and menopause. J Menopausal Med. 2019;25:83–87. doi:10.6118/jmm.19192

3.     Nowakowski S, Meers JM. Cognitive behavioral therapy for insomnia and wom- en’s health: sex as a biological variable. Sleep Med Clin. 2019;14:185–197. doi:10.1016/j.jsmc.2019.01.002

4.     Cheng Y-S, Tseng P-T, Wu M-K, et al. Pharmacologic and hormonal treatments for menopausal sleep disturbances: a network meta-analysis of 43 randomized controlled trials and 32,271 menopausal women. Sleep Med Rev. 2021;57:101469. doi:10.1016/j.smrv.2021.101469

5.     Hood S, Amir S. The aging clock: circadian rhythms and later life. J Clin Invest. 2017;127:437–446. doi:10.1172/JCI90328

6.     Borbely AA, Daan S, Wirz-Justice A, et al. The two-process model of sleep regula- tion: a reappraisal. J Sleep Res. 2016;25:131–143. doi:10.1111/jsr.12371

7.     Duffy JF, Zitting KM, Chinoy ED. Aging and circadian rhythms. Sleep Med Clin. 2015;10:423–434. doi:10.1016/j.jsmc.2015.08.002

8.     Polasek D, Santhi N, Alfonso-Miller P, Walshe IH, Haskell-Ramsay CF, Elder GJ. Nutritional interventions in treating menopause-related sleep disturbances: a systematic review. Nutr Rev. 2023 Sep 11:nuad113. doi: 10.1093/nutrit/nuad113. Epub ahead of print. PMID: 37695299.

9.     Thomas AJ, Ismail R, Taylor-Swanson L, et al. Effects of isoflavones and amino acid therapies for hot flashes and co-occurring symptoms during the meno- pausal transition and early postmenopause: a systematic review. Maturitas. 2014;78:263–276. doi:10.1016/j.maturitas.2014.05.007

10.  Jiang K, Jin Y, Huang L, et al. Black cohosh improves objective sleep in postme- nopausal women with sleep disturbance. Climacteric. 2015;18:559–567. doi:10.3109/13697137.2015.1042450

11.  St-Onge MP, Mikic A, Pietrolungo CE. Effects of Diet on Sleep Quality.Adv Nutr.(2016-09)

12.  Pabon E, Greenlund IM, Carter JR, de Wit H. Effects of alcohol on sleep and nocturnal heart rate: Relationships to intoxication and morning-after effects. Alcohol Clin Exp Res. 2022 Oct;46(10):1875-1887. doi: 10.1111/acer.14921. Epub 2022 Sep 1.

13.  Wurtman, R.J.; Wurtman, J.J.; Regan, M.M.; McDermott, J.M.; Tsay, R.H.; Breu, J.J. Effects of normal meals rich in carbohydrates or proteins on plasma tryptophan and tyrosine ratios. Am. J. Clin. Nutr. 200377, 128–132.

14.  Lyons, P.M.; Truswell, A.S. Serotonin precursor influenced by type of carbohydrate meal in healthy adults. Am. J. Clin. Nutr. 198847, 433–439.

15.  Afaghi, A.; O’Connor, H.; Chow, C.M. High-glycemic-index carbohydrate meals shorten sleep onset. Am. J. Clin. Nutr. 200785, 426–430.

16.  Iao, S.I.; Jansen, E.; Shedden, K.; O’Brien, L.M.; Chervin, R.D.; Knutson, K.L.; Dunietz, G.L. Associations between bedtime eating or drinking, sleep duration and wake after sleep onset: Findings from the American time use survey. Br. J. Nutr. 2021127, 1–10.

17.  Drake C; Roehrs T; Shambroom J; Roth T. Caffeine effects on sleep taken 0, 3, or 6 hours before going to bed. J Clin Sleep Med 2013;9(11):1195-1200.

18.  Srivastava JK, Shankar E, Gupta S. Chamomile: A herbal medicine of the past with bright future. Mol Med Rep. 2010 Nov 1;3(6):895-901. doi: 10.3892/mmr.2010.377.

19. Polasek D, Santhi N, Alfonso-Miller P, Walshe IH, Haskell-Ramsay CF, Elder GJ. Nutritional interventions in treating menopause-related sleep disturbances: a systematic review. Nutr Rev. 2023 Sep 11:nuad113. doi: 10.1093/nutrit/nuad113.

20. Hirose A, Terauchi M, Akiyoshi M, et al. Low-dose isoflavone aglycone alleviates psychological symptoms of menopause in Japanese women: a randomized, double-blind, placebo-controlled study. Arch Gynecol Obstet. 2016;293:609–615. doi:10.1007/s00404-015-3849-0

21. De Franciscis P, Grauso F, Luisi A, et al. Adding Agnus castus and Magnolia to soy isoflavones relieves sleep disturbances besides postmenopausal vasomotor symptoms—long term safety and effectiveness. Nutrients. 2017;9:1–8. Doi:10.3390/nu9020129

22. Davinelli S, Scapagnini G, Marzatico F, et al. Influence of equol and resveratrol supplementation on health-related quality of life in menopausal women: a randomized, placebo-controlled study. Maturitas. 2017;96:77–83. doi:10.1016/ j.maturitas.2016.11.016

23. Purzand B, Rokhgireh S, Shabani Zanjani M, et al. The comparison of the effect of soybean and fish oil on supplementation on menopausal symptoms in postme- nopausal women: a randomized, double-blind, placebo-controlled trial. Complement Ther Clin Pract. 2020;41:101239. doi:10.1016/j.ctcp.2020.101239

 24. Guida M, Raffone A, Travaglino A, et al. Cimicifuga racemosa isopropanolic extract for menopausal symptoms: an observational prospective case–control study. Gynecol Endocrinol. 2021;37:1132–1137. doi:10.1080/ 09513590.2021.1974381

25. Jiang K, Jin Y, Huang L, et al. Black cohosh improves objective sleep in postme- nopausal women with sleep disturbance. Climacteric. 2015;18:559–567. doi:10.3109/13697137.2015.1042450

26. Auerbach L, Rakus J, Bauer C, et al. Pomegranate seed oil in women with meno- pausal symptoms: a prospective randomized, placebo-controlled, double- blinded trial. Menopause. 2012;19:426–432.

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28. Meissner HO, Reich-Bilinska H, Mscisz A, et al. Therapeutic effects of pre- gelatinized Maca (Lepidium peruvianum chacon) used as a non-hormonal alterna- tive to HRT in perimenopausal women – clinical pilot study. Int J Biomed Sci. 2006;2:143–159.

29. Mahmoudi R, Ansari S, Haghighizadeh MH, et al. Investigation the effect of jujube seed capsule on sleep quality of postmenopausal women: a double-blind randomized clinical trial. Biomedicine (Taipei). 2020;10:42–48.

30. Zeidabadi A, Yazdanpanahi Z, Dabbaghmanesh MH, et al. The effect of Salvia officinalis extract on symptoms of flushing, night sweat, sleep disorders, and score of forgetfulness in postmenopausal women. J Family Med Prim Care. 2020;9:1086–1092.